I'm developing a new site for a client (it's actually a redesign), and I'm going to town with this....
This is the works.... Responsive Design, looks good and easy to navigate even in mobile/tablet/dektop, with hidden/sliding menu panels, panel menus loaded dynamically with Ajax, etc... jQuery, typekit, etc.
I'm hot to redesign this site, because it's last redesign was 10 years ago.
Works great! Looks great!